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PDGFR??/?? 抑制剂

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产品目录号: A11350


产品名 目录号 价格 数量
CP-673451 5mg A11350-5
¥ 1,200.00
CP-673451 10mg A11350-10
¥ 2,000.00
CP-673451 25mg A11350-25
¥ 3,800.00
CP-673451 50mg A11350-50
¥ 6,800.00
CP-673451 10mM * 1mL in DMSO A11350-10mM-D
¥ 1,590.00



CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM.





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 CP-673451 发表的文献 (1)
  • Kaori Aoto, .et al. Complex formation between platelet-derived growth factor receptor 汕 and transforming growth factor 汕 receptor regulates the differentiation of mesenchymal stem cells into cancer-associated fibroblasts, Oncotarget, 2018, Sep 25; 9(75): 34090每34102 PMID: 30344924

Chemical Information

目录号 A11350
Mechanism of action Inhibitor
分子量 417.5
化学分子式 C24H27N5O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 343787-29-1
Synonyms CP673451
化学名称 1-(2-(5-(2-methoxyethoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine


CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM.
Target Value
PDGFRαIC50: 10nM
c-KitIC50: 252nM
VEGFR1IC50: 450nM
VEGFR2IC50: 450nM
LCKIC50: >1μM
SrcIC50: >2μM
v-AblIC50: >5μM
Tie-2IC50: >5μM
bFGFRIC50: >5μM
EGFRIC50: >10μM
ErbB2IC50: >10μM
c-MetIC50: >10μM
IGF-1RIC50: >10μM


Solubility (25°C)* In vitro DMSO 28 mg/mL heating (67.06 mM)
Water <1 mg/mL (<1 mM)
Ethanol 4 mg/mL (9.58 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.95 mL 119.76 mL 239.52mL
0.5 mM 4.79 mL 23.95 mL 47.9 mL
1 mM 2.4 mL 11.98 mL 23.95 mL
5 mM 0.48 mL 2.4 mL 4.79 mL

*The above data is based on the productmolecular weight 417.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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