CPI-169
目录号: A15920
EZH2 抑制剂
CPI-169 是一种强效且选择性的 EZH2 抑制剂,其 IC50 分别为 0.24 nM、0.51 nM 和 6.1 nM,针对 EZH2 WT、EZH2 Y641N 和 EZH1。
| Discription | CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively. | ||
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| Targets |
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| 目录号 | A15920 |
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| 分子式 | C27H36N4O5S |
| 分子量 | 528.66 |
| CAS号 | 1450655-76-1 |
| SMILES | CCS(N1CCC([C@@](N2C(C)=C(/C(O)=N/CC(C(O)=N3)=C(OC)C=C3C)C4=CC=CC=C42)([H])C)CC1)(=O)=O |
| 其他名称 | CPI 169, CPI169 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 88 mg/mL (166.45 mM) | |
| Water | Insoluble | ||
| Ethanol | 88 mg/mL (166.45 mM) | ||
| In vivo | 10% DMSO+60% PEG 400+30% ddH2O | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.92 mL | 94.58 mL | 189.16 mL |
| 0.5 mM | 3.78 mL | 18.92 mL | 37.83 mL |
| 1 mM | 1.89 mL | 9.46 mL | 18.92 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2