Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody engineered to selectively bind to and inhibit the glucagon receptor (GCGR). This antibody demonstrates a high affinity for GCGR with a dissociation constant (K_D) of 0.1 nM, indicating potent binding capability. Crotedumab is primarily utilized in diabetes research, where modulation of the glucagon receptor is implicated in glucose homeostasis and diabetic pathology.
Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody engineered to selectively bind to and inhibit the glucagon receptor (GCGR). This antibody demonstrates a high affinity for GCGR with a dissociation constant (K_D) of 0.1 nM, indicating potent binding capability. Crotedumab is primarily utilized in diabetes research, where modulation of the glucagon receptor is implicated in glucose homeostasis and diabetic pathology.
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