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Cryptotanshinone

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Stat3 抑制剂

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产品目录号: A10244

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Cryptotanshinone 10mg A10244-10
¥ 400.00
Cryptotanshinone 25mg A10244-25
¥ 900.00
Cryptotanshinone 50mg A10244-50
¥ 1,700.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bunge (Danshen), dramatically blocks STAT3 Tyr705 phosphorylation but not STAT3 Ser727 phosphorylation in DU145 cells, and significantly inhibits JAK2 phosphorylation with IC50 of ~5 μM without affecting the phosphorylation of upstream kinases c-Src and EGFR.

Cryptotanshinone

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Chemical Information

目录号 A10244
Mechanism of action Inhibitor
分子量 296.4
化学分子式 C19H20O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 35825-57-1
Synonyms Tanshinone
SMILES code C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
化学名称 (r)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione

生物活性

Description
Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bunge (Danshen), dramatically blocks STAT3 Tyr705 phosphorylation but not STAT3 Ser727 phosphorylation in DU145 cells, and significantly inhibits JAK2 phosphorylation with IC50 of ~5 μM without affecting the phosphorylation of upstream kinases c-Src and EGFR.
Targets
STAT3 (HCT-116 cells)
4.6 μM

溶解性

Solubility (25°C)* In vitro DMSO 5 mg/mL heating (16.87 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL heating (3.37 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.74 mL 168.69 mL 337.38mL
0.5 mM 6.75 mL 33.74 mL 67.48 mL
1 mM 3.37 mL 16.87 mL 33.74 mL
5 mM 0.67 mL 3.37 mL 6.75 mL

*The above data is based on the productmolecular weight 296.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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