Cryptotanshinone

目录号: A10244

Stat3 inhibitor

Cryptotanshinone Chemical Structure

CAS NO. 35825-57-1

Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bunge (Danshen), dramatically blocks STAT3 Tyr705 phosphorylation but not STAT3 Ser727 phosphorylation in DU145 cells, and significantly inhibits JAK2 phosphorylation with IC50 of ~5 μM without affecting the phosphorylation of upstream kinases c-Src and EGFR.

库存: 现货

规格 价格 数量
10 mg
¥ 400.00
25 mg
¥ 900.00
50 mg
¥ 1,700.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bunge (Danshen), dramatically blocks STAT3 Tyr705 phosphorylation but not STAT3 Ser727 phosphorylation in DU145 cells, and significantly inhibits JAK2 phosphorylation with IC50 of ~5 μM without affecting the phosphorylation of upstream kinases c-Src and EGFR.
Targets
STAT3 (HCT-116 cells)
4.6 μM
In vitro DMSO 5 mg/mL heating (16.87 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL heating (3.37 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.74 mL 168.69 mL 337.38 mL
0.5 mM 6.75 mL 33.74 mL 67.48 mL
1 mM 3.37 mL 16.87 mL 33.74 mL
5 mM 0.67 mL 3.37 mL 6.75 mL

*The above data is based on the productmolecular weight 296.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10244
MECHANISM OF ACTION Inhibitor
M. Wt 296.4
Formula C19H20O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 35825-57-1
Synonyms Tanshinone
SMILES C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C

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