CTX-471 is a fully human monoclonal antibody targeting CD137, a receptor involved in the regulation of immune responses. This antibody demonstrates high binding affinity to recombinant CD137 from various species, with dissociation constants (Kd) of 50 nM for human, 61 nM for cynomolgus macaque, and 748 nM for mouse CD137. CTX-471 is primarily utilized in research focused on immunomodulation and oncology, offering a valuable tool for studies aimed at understanding and manipulating immune pathways in cancer therapy.
CTX-471 is a fully human monoclonal antibody targeting CD137, a receptor involved in the regulation of immune responses. This antibody demonstrates high binding affinity to recombinant CD137 from various species, with dissociation constants (Kd) of 50 nM for human, 61 nM for cynomolgus macaque, and 748 nM for mouse CD137. CTX-471 is primarily utilized in research focused on immunomodulation and oncology, offering a valuable tool for studies aimed at understanding and manipulating immune pathways in cancer therapy.
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