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CUDC-101

促销

HDAC 抑制剂

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产品目录号: A10246

库存状态:中国现货中国现货

产品名 目录号 价格 数量
CUDC-101 10mg A10246-10
¥ 700.00
CUDC-101 50mg A10246-50
¥ 2,600.00
CUDC-101 100mg A10246-100
¥ 4,800.00
CUDC-101 200mg A10246-200
¥ 7,200.00
CUDC-101 10mM * 1mL in DMSO A10246-10mM-D
¥ 890.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2.

CUDC-101

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Chemical Information

目录号 A10246
Mechanism of action Inhibitor
分子量 434.5
化学分子式 C24H26N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1012054-59-9
Synonyms CUDC101
SMILES code COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO
化学名称 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide

生物活性

Description
CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2.
Targets
Target Value
EGFRIC50: 2.4nM
HDACIC50: 4.4nM
HDAC1IC50: 4.5nM
HDAC6IC50: 5.1nM
HDAC3IC50: 9.1nM
HDAC5IC50: 11.4nM
HDAC2IC50: 12.6nM
HDAC4IC50: 13.2nM
HER2IC50: 15.7nM
HDAC10IC50: 26.1nM
HDAC9IC50: 67.2nM
HDAC8IC50: 79.8nM
HDAC7IC50: 373nM

溶解性

Solubility (25°C) * In vitro DMSO 20 mg/mL (46.03 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.01 mL 115.07 mL 230.15mL
0.5 mM 4.6 mL 23.01 mL 46.03 mL
1 mM 2.3 mL 11.51 mL 23.01 mL
5 mM 0.46 mL 2.3 mL 4.6 mL

*The above data is based on the productmolecular weight 434.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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