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CUDC-305 (DEBIO-0932 )

HSP90 抑制剂

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产品目录号: A12648

库存状态:中国现货中国现货

产品名 目录号 价格 数量
CUDC-305 (DEBIO-0932 ) 5mg A12648-5
¥ 1,100.00
CUDC-305 (DEBIO-0932 ) 10mg A12648-10
¥ 1,700.00
CUDC-305 (DEBIO-0932 ) 25mg A12648-25
¥ 3,500.00
CUDC-305 (DEBIO-0932 ) 50mg A12648-50
¥ 5,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Debio 0932 is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents.

CUDC-305 (DEBIO-0932 )

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Chemical Information

目录号 A12648
Mechanism of action Inhibitor
分子量 442.58
化学分子式 C22H30N6O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1061318-81-7
Synonyms Debio0932; CUDC305
SMILES code CC(C)(C)CNCCN1C2=C(C(=NC=C2)N)N=C1SC3=CC4=C(C=C3N(C)C)OCO4
化学名称 2-((6-(dimethylamino)benzo[d][1,3]dioxol-5-yl)thio)-1-(2-(neopentylamino)ethyl)-1H-imidazo[4,5-c]pyridin-4-amine

生物活性

Description
Debio 0932 is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.59 mL 112.97 mL 225.95mL
0.5 mM 4.52 mL 22.59 mL 45.19 mL
1 mM 2.26 mL 11.3 mL 22.59 mL
5 mM 0.45 mL 2.26 mL 4.52 mL

*The above data is based on the productmolecular weight 442.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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