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CUDC-305 (DEBIO-0932) 是一种新型的热休克蛋白90（HSP90）抑制剂，对HSP90 alpha/beta具有很强的亲和力，对HSP90α和HSP90β的IC50值分别为100和103nM。具有很高的口服生物利用度，并且对多种癌细胞系均具有强大的抗增殖活性（平均IC50为220 nmol/L）。包括许多对护理标准（SOC）药物有抵抗力的非小细胞肺癌（NSCLC）细胞系。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.59 mL | 112.97 mL | 225.95 mL |
| 0.5 mM | 4.52 mL | 22.59 mL | 45.19 mL |
| 1 mM | 2.26 mL | 11.3 mL | 22.59 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.52 mL |
*The above data is based on the productmolecular weight 442.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12648 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 442.58 |
| Formula | C22H30N6O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1061318-81-7 |
| Synonyms | Debio0932; CUDC305 |
| SMILES | CC(C)(C)CNCCN1C2=C(C(=NC=C2)N)N=C1SC3=CC4=C(C=C3N(C)C)OCO4 |
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