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CUDC-907

促销

HDAC 抑制剂

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产品目录号: A11153

库存状态:中国现货中国现货

产品名 目录号 价格 数量
CUDC-907 5mg A11153-5
¥ 1,500.00
CUDC-907 10mg A11153-10
¥ 2,800.00
CUDC-907 50mg A11153-50
¥ 6,200.00
CUDC-907 100mg A11153-100
¥ 10,500.00
CUDC-907 10mM * 1mL in DMSO A11153-10mM-D
¥ 1,600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

CUDC-907 is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.

CUDC-907

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Chemical Information

目录号 A11153
Mechanism of action Inhibitor
分子量 508.6
化学分子式 C23H24N8O4S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1339928-25-4
Synonyms CUDC907
SMILES code CN(CC1=CC2=C(S1)C(=NC(=N2)C3=CN=C(C=C3)OC)N4CCOCC4)C5=NC=C(C=N5)C(=O)NO
化学名称 N-hydroxy-2-(((2-(6-methoxypyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxamide

生物活性

Description
CUDC-907 is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.
Targets
Target Value
HDAC1IC50: 1.7nM
HDAC3IC50: 1.8nM
HDAC10IC50: 2.8nM
HDAC2IC50: 5.0nM
HDAC11IC50: 5.4nM
PI3KαIC50: 19nM
HDAC6IC50: 27nM
PI3KδIC50: 39nM
PI3KβIC50: 54nM
HDAC8IC50: 191nM
PI3KγIC50: 311nM
HDAC4IC50: 409nM
HDAC7IC50: 426nM
HDAC9IC50: 554nM
HDAC5IC50: 674nM

溶解性

Solubility (25°C)* In vitro DMSO 102 mg/mL (200.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.66 mL 98.31 mL 196.62mL
0.5 mM 3.93 mL 19.66 mL 39.32 mL
1 mM 1.97 mL 9.83 mL 19.66 mL
5 mM 0.39 mL 1.97 mL 3.93 mL

*The above data is based on the productmolecular weight 508.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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