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CX-5461

促销

DNA/RNA Synthesis 抑制剂

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产品目录号: A11065

库存状态:中国现货中国现货

产品名 目录号 价格 数量
CX-5461 5mg A11065-5
¥ 900.00
CX-5461 10mg A11065-10
¥ 1,600.00
CX-5461 50mg A11065-50
¥ 4,500.00
CX-5461 100mg A11065-100
¥ 7,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage.

CX-5461

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 CX-5461 发表的文献 (5)
  • Hiroaki Suzuki, .et al. The proline每arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesi, Cell Death Dis, 2018, Oct; 9(10): 975 PMID: 30250194
  • Anastasia Gelgor, .et al. Nucleolar stress enhances lytic reactivation of the Kaposi*s sarcoma-associated herpesvirus, Oncotarget, 2018, Mar 2; 9(17): 13822每13833 PMID: 29568397
  • Wang ZF, .et al. The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules, Cell Chem Biol, 2018, Nov 29. pii: S2451-9456(18)30378-7 PMID: 30503283
  • Yuko Fujiwara, .et al. A Nucleolar Stress每Specific p53每miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network, EBioMedicine, 2018, Jul; 33: 33每48 PMID: 30049386
  • Ma?“mouna Coura Kone, .et al. Three-Dimensional Distribution of UBF and Nopp140 in Relationship to Ribosomal DNA Transcription During Mouse Preimplantation Development, Biol Reprod, 2016, Apr;94(4):95, 1每12 PMID: 26984997

Chemical Information

目录号 A11065
Mechanism of action Inhibitor
分子量 513.6
化学分子式 C27H27N7O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1138549-36-6
Synonyms CX5461
SMILES code CC1=CN=C(C=N1)CNC(=O)C2=C3N(C4=CC=CC=C4S3)C5=C(C2=O)C=CC(=N5)N6CCCN(CC6)C
化学名称 2-(4-methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide

生物活性

Description
CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage.
Targets
A375 MIA PaCa-2 Pol I-driven transcription of rRNA (HCT-116, A375, MIA PaCa-2 cells) HCT-116
58 nM(ED50)74 nM(ED50)142 nM167 nM(ED50)

溶解性

Solubility (25°C)* In vitro DMSO 0.02 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.47 mL 97.35 mL 194.7mL
0.5 mM 3.89 mL 19.47 mL 38.94 mL
1 mM 1.95 mL 9.74 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL

*The above data is based on the productmolecular weight 513.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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