CX-5461
CX-5461 是一种首创的非基因毒性小分子，针对 RNA 聚合酶 I (Pol I) 的靶向抑制剂，能够激活 p53 通路而不引起 DNA 损伤。它抑制 RNA 聚合酶 I 驱动的 rRNA 转录，其在 HCT-116、A375 和 MIA PaCa-2 细胞中的 IC50 分别为 142、113 和 54 nM。
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Adooq用户使用CX-5461发表的13篇文献
生物活性
| Discription | CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively |
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产品信息
| 目录号 | A11065 |
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| 分子式 | C27H27N7O2S |
| 分子量 | 513.6 |
| CAS号 | 1138549-36-6 |
| SMILES | CC1=CN=C(C=N1)CNC(=O)C2=C3N(C4=CC=CC=C4S3)C5=C(C2=O)C=CC(=N5)N6CCCN(CC6)C |
| 其他名称 | CX5461 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | <1 mg/mL | |
| Water | Insoluble | ||
| Ethanol | DMF: Warmed: 3 mg/mL (5.84 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.47 mL | 97.35 mL | 194.7 mL |
| 0.5 mM | 3.89 mL | 19.47 mL | 38.94 mL |
| 1 mM | 1.95 mL | 9.74 mL | 19.47 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.89 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1138549-36-6 | 1138549-36-6 供应商 | 1138549-36-6 花费 | 1138549-36-6 生产商 | 订购 1138549-36-6 | 1138549-36-6 代理商