CX-5461

Name: CX-5461
SKU: A11065

目录号: A11065

DNA/RNA Synthesis 抑制剂

Product Citations (10)

CX-5461 Chemical Structure

CAS NO. 1138549-36-6

CX-5461是RNA聚合酶I（Pol I）的一流的非遗传毒性小分子靶向抑制剂，可激活p53途径而不会引起DNA损伤。

库存：现货

规格	价格	数量
5 mg	￥ 900.00
10 mg	￥ 1,600.00
50 mg	￥ 4,500.00
100 mg	￥ 7,500.00

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生物活性

CX-5461是RNA聚合酶I（Pol I）的一流的非遗传毒性小分子靶向抑制剂，可激活p53途径而不会引起DNA损伤。

靶点信息

A375	MIA PaCa-2	Pol I-driven transcription of rRNA (HCT-116, A375, MIA PaCa-2 cells)	HCT-116
58 nM(ED50)	74 nM(ED50)	142 nM	167 nM(ED50)

溶解度 *

In vitro	DMSO	<1 mg/mL
	Water	Insoluble
	Ethanol	DMF: Warmed: 3 mg/mL (5.84 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.47 mL	97.35 mL	194.7 mL
0.5 mM	3.89 mL	19.47 mL	38.94 mL
1 mM	1.95 mL	9.74 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL

*The above data is based on the productmolecular weight 513.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11065
作用机制	Inhibitor (抑制剂)
M. Wt	513.6
Formula	C27H27N7O2S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1138549-36-6
Synonyms	CX5461
SMILES	CC1=CN=C(C=N1)CNC(=O)C2=C3N(C4=CC=CC=C4S3)C5=C(C2=O)C=CC(=N5)N6CCCN(CC6)C