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CX-6258 HCl

Pan-PIM kinase 抑制剂

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产品目录号: A14275

库存状态:中国现货中国现货

产品名 目录号 价格 数量
CX-6258 HCl 5mg A14275-5
¥ 1,100.00
CX-6258 HCl 10mg A14275-10
¥ 1,800.00
CX-6258 HCl 25mg A14275-25
¥ 4,000.00
CX-6258 HCl 10mM * 1mL in DMSO A14275-10mM-D
¥ 1,690.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3.

CX-6258 HCl

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Chemical Information

目录号 A14275
Mechanism of action Inhibitor
分子量 498.4
化学分子式 C26H24ClN3O3.HCl
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1353859-00-3
Synonyms CX6258
SMILES code CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)/C=C/4\C5=C(C=CC(=C5)Cl)NC4=O.Cl
化学名称 (3E)-5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-Indol-2-one, hydrochloride (1:1)

生物活性

Description
CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3.
Targets
Pim1 Pim3 Pim2
5 nM16 nM25 nM

溶解性

Solubility (25°C)* In vitro DMSO 57 mg/mL heating (114.36 mM)
Water 89 mg/mL heating (178.57 mM)
Ethanol 1 mg/mL heating (2.0 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.06 mL 100.32 mL 200.64mL
0.5 mM 4.01 mL 20.06 mL 40.13 mL
1 mM 2.01 mL 10.03 mL 20.06 mL
5 mM 0.4 mL 2.01 mL 4.01 mL

*The above data is based on the productmolecular weight 498.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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