CX-6258 HCl

Name: CX-6258 HCl
SKU: A14275

目录号: A14275

Pan-PIM kinase 抑制剂

CX-6258 HCl Chemical Structure

CAS NO. 1353859-00-3

CX-6258 HCl是一种有效的口服泛Pim激酶抑制剂，对Pim1，Pim2和Pim3的IC50为5 nM，25 nM和16 nM。

库存：现货

规格	价格	数量
5 mg	￥ 1,100.00
10 mg	￥ 1,800.00
25 mg	￥ 4,000.00
10mM * 1mL in DMSO	￥ 1,690.00

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生物活性

CX-6258 HCl是一种有效的口服泛Pim激酶抑制剂，对Pim1，Pim2和Pim3的IC50为5 nM，25 nM和16 nM。

靶点信息

Pim1	Pim3	Pim2
5 nM	16 nM	25 nM

溶解度 *

In vitro	DMSO	Warmed: 55 mg/mL (110.35 mM)
	Water	Warmed: 86 mg/mL (172.55 mM)
	Ethanol	Warmed: 1 mg/mL (2 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.06 mL	100.32 mL	200.64 mL
0.5 mM	4.01 mL	20.06 mL	40.13 mL
1 mM	2.01 mL	10.03 mL	20.06 mL
5 mM	0.4 mL	2.01 mL	4.01 mL

*The above data is based on the productmolecular weight 498.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14275
作用机制	Inhibitor (抑制剂)
M. Wt	498.4
Formula	C26H24ClN3O3.HCl
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1353859-00-3
Synonyms	CX6258
SMILES	CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)/C=C/4\C5=C(C=CC(=C5)Cl)NC4=O.Cl