Cyclopamine

目录号: A10249

Hedgehog signaling 抑制剂

Cyclopamine

Cyclopamine Chemical Structure

CAS NO. 4449-51-8

Cyclopamine是一种特异性的Hedgehog (Hh)信号通路拮抗剂,作用于Smoothened (Smo),IC50为46 nM。Cyclopamine 抑制Hedgehog信号通路, IC50 为46 nM。

库存: 现货

规格 价格 数量
5 mg
¥ 450.00
10 mg
¥ 700.00
50 mg
¥ 1,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Cyclopamine是一种特异性的Hedgehog (Hh)信号通路拮抗剂,作用于Smoothened (Smo),IC50为46 nM。Cyclopamine 抑制Hedgehog信号通路, IC50 为46 nM。
靶点信息
Smoothened (TM3Hh12 cells)
46 nM
In vitro DMSO Insoluble
Water DMF Warmed: 9 mg/mL (21.86 mM)
Ethanol Warmed: 2 mg/mL (4.85 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.3 mL 121.48 mL 242.95 mL
0.5 mM 4.86 mL 24.3 mL 48.59 mL
1 mM 2.43 mL 12.15 mL 24.3 mL
5 mM 0.49 mL 2.43 mL 4.86 mL

*The above data is based on the productmolecular weight 411.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10249
作用机制 Inhibitor (抑制剂)
M. Wt 411.6
Formula C27H41NO2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 4449-51-8
Synonyms 11-deoxojervine
SMILES C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1

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