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Dabrafenib (GSK2118436A)


Raf 抑制剂

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产品目录号: A11381


产品名 目录号 价格 数量
Dabrafenib 5mg A11381-5
¥ 500.00
Dabrafenib 25mg A11381-25
¥ 900.00
Dabrafenib 50mg A11381-50
¥ 1,500.00
Dabrafenib 100mg A11381-100
¥ 2,400.00
Dabrafenib (GSK2118436A) 10mM * 1mL in DMSO A11381-10mM-D
¥ 550.00



Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.

Dabrafenib  (GSK2118436A)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Dabrafenib (GSK2118436A) 发表的文献 (3)
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635每646 PMID: 29917168
  • Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Chemical Information

目录号 A11381
Mechanism of action Inhibitor
分子量 519.6
化学分子式 C23H20F3N5O2S2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1195765-45-7
Synonyms GSK2118436A
SMILES code CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
化学名称 N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide


Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.
B-Raf (V600E) (Cell-free assay) B-Raf (Cell-free assay) C-Raf (Cell-free assay)
0.8 nM3.2 nM5.0 nM


Solubility (25°C) * In vitro DMSO 30 mg/mL (57.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.25 mL 96.23 mL 192.46mL
0.5 mM 3.85 mL 19.25 mL 38.49 mL
1 mM 1.92 mL 9.62 mL 19.25 mL
5 mM 0.38 mL 1.92 mL 3.85 mL

*The above data is based on the productmolecular weight 519.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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