Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

Dabrafenib (GSK2118436A)

促销

Raf 抑制剂

0 Customer Reviews
产品目录号: A11381

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Dabrafenib 5mg A11381-5
¥ 500.00
Dabrafenib 25mg A11381-25
¥ 900.00
Dabrafenib 50mg A11381-50
¥ 1,500.00
Dabrafenib 100mg A11381-100
¥ 2,400.00
Dabrafenib (GSK2118436A) 10mM * 1mL in DMSO A11381-10mM-D
¥ 550.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.

Dabrafenib  (GSK2118436A)

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Dabrafenib (GSK2118436A) 发表的文献 (3)
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635每646 PMID: 29917168
  • Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Chemical Information

目录号 A11381
Mechanism of action Inhibitor
分子量 519.6
化学分子式 C23H20F3N5O2S2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1195765-45-7
Synonyms GSK2118436A
SMILES code CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
化学名称 N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

生物活性

Description
Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.
Targets
B-Raf (V600E) (Cell-free assay) B-Raf (Cell-free assay) C-Raf (Cell-free assay)
0.8 nM3.2 nM5.0 nM

溶解性

Solubility (25°C) * In vitro DMSO 30 mg/mL (57.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.25 mL 96.23 mL 192.46mL
0.5 mM 3.85 mL 19.25 mL 38.49 mL
1 mM 1.92 mL 9.62 mL 19.25 mL
5 mM 0.38 mL 1.92 mL 3.85 mL

*The above data is based on the productmolecular weight 519.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

View Related Products By Research Topics

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

其他人对该产品使用了下列标签:

使用空格分隔标签。使用单引号(')标注词组。

Similar product(s)


Keywords:购买 Dabrafenib (GSK2118436A) | Dabrafenib (GSK2118436A) 供应商 | 订购 Dabrafenib (GSK2118436A) | Dabrafenib (GSK2118436A) 价格 | Dabrafenib (GSK2118436A) 生产商 | 订单 Dabrafenib (GSK2118436A) | Dabrafenib (GSK2118436A) 代理商 | 购买 1195765-45-7| 1195765-45-7 供应商 | 订购 1195765-45-7 | 1195765-45-7 价格 | 1195765-45-7 生产商 | 订单 1195765-45-7 | 1195765-45-7 代理商|buy Dabrafenib (GSK2118436A) | Dabrafenib (GSK2118436A) Supplier | purchase Dabrafenib (GSK2118436A) | Dabrafenib (GSK2118436A) cost | Dabrafenib (GSK2118436A) manufacturer | order Dabrafenib (GSK2118436A) | Dabrafenib (GSK2118436A) distributor | buy 1195765-45-7| 1195765-45-7 Supplier | purchase 1195765-45-7 | 1195765-45-7 cost | 1195765-45-7 manufacturer | order 1195765-45-7 | 1195765-45-7 distributor