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Danoprevir (RG7227)

促销

HCV NS3/4A protease 抑制剂

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产品目录号: A10284

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Danoprevir 2mg A10284-2
¥ 600.00
Danoprevir 5mg A10284-5
¥ 1,200.00
Danoprevir 10mg A10284-10
¥ 2,000.00
Danoprevir 50mg A10284-50
¥ 6,000.00
Danoprevir (RG7227) 10mM * 1mL in DMSO A10284-10mM-D
¥ 2,740.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.

Danoprevir (RG7227)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Danoprevir (RG7227) 发表的文献 (2)
  • In那s GARCEZ PALHA, .et al. An in vivo translation-reporter system for the study of protein synthesis in zebrafish embryos, Biol Open, 2018, Nov 7 PMID: 30404898
  • Hui Shen, .et al. Inhibitory Effects of Caffeic Acid Phenethyl Ester Derivatives on Replication of Hepatitis C Virus, PLoS One., 2013, 8(12): e82299 PMID: 24358168

Chemical Information

目录号 A10284
Mechanism of action Inhibitor
分子量 717.9
化学分子式 C35H48FN5O8S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 850876-88-9
Synonyms RG7227, ITMN-191, RO5190591
SMILES code CC(C)(C)OC(=O)N[C@H]1CCCCC/C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]3C[C@H](CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)NS(=O)(=O)C6CC6
化学名称 4-Fluoro-1,3-dihydro-2H-isoindole-2-carboxylic acid

生物活性

Description
Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.
Targets
HCV NS3/4A protease
0.2 nM-3.5 nM

溶解性

Solubility (25°C)* In vitro DMSO 144 mg/mL (196.76 mM)
Water <1 mg/mL (<1 mM)
Ethanol 144 mg/mL (196.76 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.93 mL 69.65 mL 139.3mL
0.5 mM 2.79 mL 13.93 mL 27.86 mL
1 mM 1.39 mL 6.96 mL 13.93 mL
5 mM 0.28 mL 1.39 mL 2.79 mL

*The above data is based on the productmolecular weight 717.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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