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Danusertib (PHA-739358)

促销

Aurora 抑制剂

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产品目录号: A10715

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Danusertib 5mg A10715-5
¥ 1,000.00
Danusertib 10mg A10715-10
¥ 1,800.00
Danusertib 25mg A10715-25
¥ 3,500.00
Danusertib 50mg A10715-50
¥ 5,600.00
Danusertib (PHA-739358) 10mM * 1mL in DMSO A10715-10mM-D
¥ 1,200.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2

Danusertib (PHA-739358)

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Chemical Information

目录号 A10715
Mechanism of action Inhibitor
分子量 474.6
化学分子式 C26H30N6O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 827318-97-8
Synonyms PHA739358
SMILES code CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)[C@@H](C5=CC=CC=C5)OC
化学名称 N-[5-((2R)-2-Methoxy-2-phenylethanoyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide

生物活性

Description
Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2
Targets
Target Value
AuroraAIC50: 13nM
AblIC50: 25nM
RETIC50: 31nM
TrkAIC50: 31nM
FGFR1IC50: 47nM
AuroraCIC50: 61nM
AuroraBIC50: 79nM

溶解性

Solubility (25°C) * In vitro DMSO 95 mg/mL (200.18 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.07 mL 105.35 mL 210.7mL
0.5 mM 4.21 mL 21.07 mL 42.14 mL
1 mM 2.11 mL 10.54 mL 21.07 mL
5 mM 0.42 mL 2.11 mL 4.21 mL

*The above data is based on the productmolecular weight 474.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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