Danusertib (PHA-739358) Chemical Structure

CAS NO. 827318-97-8

Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2

库存: 现货

规格 价格 数量
5 mg
¥ 1,000.00
10 mg
¥ 1,800.00
25 mg
¥ 3,500.00
50 mg
¥ 5,600.00
10mM * 1mL in DMSO
¥ 1,200.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2
Targets
Target Value
AuroraAIC50: 13nM
AblIC50: 25nM
RETIC50: 31nM
TrkAIC50: 31nM
FGFR1IC50: 47nM
AuroraCIC50: 61nM
AuroraBIC50: 79nM
In vitro (25°C) DMSO 95 mg/mL (200.18 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.07 mL 105.35 mL 210.7 mL
0.5 mM 4.21 mL 21.07 mL 42.14 mL
1 mM 2.11 mL 10.54 mL 21.07 mL
5 mM 0.42 mL 2.11 mL 4.21 mL

*The above data is based on the productmolecular weight 474.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10715
MECHANISM OF ACTION Inhibitor
M. Wt 474.6
Formula C26H30N6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 827318-97-8
Synonyms PHA739358
SMILES CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)[C@@H](C5=CC=CC=C5)OC

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