Danusertib (PHA-739358)

Name: Danusertib (PHA-739358)
SKU: A10715
Price: 315 CNY
Rating: 5 (1 reviews)

目录号: A10715

Aurora 抑制剂

1 篇发表文献

Danusertib (PHA-739358) 是一种针对 Aurora A/B/C 的 Aurora 激酶抑制剂，在无细胞试验中的 IC50 分别为 13 nM/79 nM/61 nM，对 Abl、TrkA、c-RET 和 FGFR1 有适度的抑制效力，对 Lck、VEGFR2/3、c-Kit、CDK2 等的抑制效力较低。目前处于临床试验第二阶段。

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Grouped product items
规格	价格	库存
1mg	¥315.00	现货
2mg	¥490.00	现货
5mg	¥665.00	现货
10mg	¥1,225.00	现货
25mg	¥2,415.00	现货
50mg	¥3,885.00	现货
100mg	¥5,810.00	现货
500mg	¥11,795.00	现货
*10mM 1mL in DMSO**	¥805.00	现货
更大包装	更多折扣

大包装询价

Notify me when the price drops

全国免运费, 顺丰次日达

重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Danusertib (PHA-739358)发表的1篇文献

Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138

生物活性

Discription

Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10715
分子式	C26H30N6O3
分子量	474.6
CAS号	827318-97-8
SMILES	CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)[C@@H](C5=CC=CC=C5)OC
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	93 mg/mL (195.97 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.07 mL	105.35 mL	210.7 mL
0.5 mM	4.21 mL	21.07 mL	42.14 mL
1 mM	2.11 mL	10.54 mL	21.07 mL
5 mM	0.42 mL	2.11 mL	4.21 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords: 购买 Danusertib (PHA-739358) | Danusertib (PHA-739358) 供应商 | Danusertib (PHA-739358) 花费 | Danusertib (PHA-739358) 生产商 | 订购 Danusertib (PHA-739358) | Danusertib (PHA-739358) 代理商 | 购买 827318-97-8 | 827318-97-8 供应商 | 827318-97-8 花费 | 827318-97-8 生产商 | 订购 827318-97-8 | 827318-97-8 代理商