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Gamma secretase 抑制剂

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产品目录号: A10288


产品名 目录号 价格 数量
DAPT (GSI-IX) 5mg A10288-5
¥ 400.00
DAPT (GSI-IX) 10mg A10288-10
¥ 700.00
DAPT (GSI-IX) 50mg A10288-50
¥ 2,500.00
DAPT (GSI-IX) 100mg A10288-100
¥ 4,000.00
DAPT (GSI-IX) 10mM * 1mL in DMSO A10288-10mM-D
¥ 940.00



DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 DAPT (GSI-IX) 发表的文献 (1)
  • Tatsuya Usui, .et al. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture, Int J Mol Sci, 2018, Apr; 19(4): 1098 PMID: 29642386

Chemical Information

目录号 A10288
Mechanism of action Inhibitor
分子量 432.5
化学分子式 C23H26F2N2O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 208255-80-5
Synonyms GSIIX
SMILES code C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
化学名称 N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester


DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
Aβ (HEK 293 cells) γ secretase(Aβ) (HEK 293 cells)
20 nM20 nM


Solubility (25°C) * In vitro DMSO 86 mg/mL (198.86 mM)
Water <1 mg/mL (<1 mM)
Ethanol 50 mg/mL (115.61 mM)
In vivo 5% DMSO/95% Corn oil 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.12 mL 115.61 mL 231.21mL
0.5 mM 4.62 mL 23.12 mL 46.24 mL
1 mM 2.31 mL 11.56 mL 23.12 mL
5 mM 0.46 mL 2.31 mL 4.62 mL

*The above data is based on the productmolecular weight 432.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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