DAPT (GSI-IX)

Name: DAPT (GSI-IX)
SKU: A10288

目录号: A10288

Gamma secretase 抑制剂

Product Citations (2)

DAPT (GSI-IX) Chemical Structure

CAS NO. 208255-80-5

DAPT (GSI-IX)是一种γ-分泌酶抑制剂，可导致人原代神经元培养物中Aβ40和Aβ42水平降低，总Aβ和Aβ42的IC50值分别为115和200 nM。

库存：现货

规格	价格	数量
5 mg	￥ 400.00
10 mg	￥ 700.00
25 mg	￥ 1,300.00
50 mg	￥ 2,500.00
100 mg	￥ 4,000.00
10mM * 1mL in DMSO	￥ 940.00

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生物活性

DAPT (GSI-IX)是一种γ-分泌酶抑制剂，可导致人原代神经元培养物中Aβ40和Aβ42水平降低，总Aβ和Aβ42的IC50值分别为115和200 nM。

靶点信息

Aβ (HEK 293 cells)	γ secretase(Aβ) (HEK 293 cells)
20 nM	20 nM

溶解度 *

In vitro (25°C)	DMSO	79 mg/mL (182.67 mM)
	Water	Insoluble
	Ethanol	46 mg/mL (106.36 mM)
In vivo	4% DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.12 mL	115.61 mL	231.21 mL
0.5 mM	4.62 mL	23.12 mL	46.24 mL
1 mM	2.31 mL	11.56 mL	23.12 mL
5 mM	0.46 mL	2.31 mL	4.62 mL

*The above data is based on the productmolecular weight 432.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10288
作用机制	Inhibitor (抑制剂)
M. Wt	432.5
Formula	C23H26F2N2O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	208255-80-5
Synonyms	GSIIX
SMILES	C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F