DAPT (GSI-IX)

目录号: A10288

Gamma secretase inhibitor

DAPT (GSI-IX) Chemical Structure

CAS NO. 208255-80-5

DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.

库存: 现货

规格 价格 数量
5 mg
¥ 400.00
10 mg
¥ 700.00
50 mg
¥ 2,500.00
100 mg
¥ 4,000.00
10mM * 1mL in DMSO
¥ 940.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
靶点信息
Aβ (HEK 293 cells) γ secretase(Aβ) (HEK 293 cells)
20 nM20 nM
In vitro (25°C) DMSO 86 mg/mL (198.86 mM)
Water <1 mg/mL (<1 mM)
Ethanol 50 mg/mL (115.61 mM)
In vivo 5% DMSO/95% Corn oil 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.12 mL 115.61 mL 231.21 mL
0.5 mM 4.62 mL 23.12 mL 46.24 mL
1 mM 2.31 mL 11.56 mL 23.12 mL
5 mM 0.46 mL 2.31 mL 4.62 mL

*The above data is based on the productmolecular weight 432.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10288
MECHANISM OF ACTION Inhibitor
M. Wt 432.5
Formula C23H26F2N2O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 208255-80-5
Synonyms GSIIX
SMILES C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F

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