Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody designed to specifically target TIGIT (T cell immune receptor with Ig domain and ITIM domains). TIGIT serves as an inhibitory immune checkpoint that plays a critical role in immune regulation by promoting NK cell depletion and diminishing cytokine secretion through its interaction with CD155. This antibody has the capability to inhibit effector T cell functions and enhance the regulation of T regulatory cells, contributing to its immunosuppressive effects. Dargistotug is pivotal in studies focused on immune checkpoint blockade and the modulation of immune responses in various diseases.
Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody designed to specifically target TIGIT (T cell immune receptor with Ig domain and ITIM domains). TIGIT serves as an inhibitory immune checkpoint that plays a critical role in immune regulation by promoting NK cell depletion and diminishing cytokine secretion through its interaction with CD155. This antibody has the capability to inhibit effector T cell functions and enhance the regulation of T regulatory cells, contributing to its immunosuppressive effects. Dargistotug is pivotal in studies focused on immune checkpoint blockade and the modulation of immune responses in various diseases.
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