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DC41SMe, a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC50s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.77 mL | 68.84 mL | 137.68 mL |
| 0.5 mM | 2.75 mL | 13.77 mL | 27.54 mL |
| 1 mM | 1.38 mL | 6.88 mL | 13.77 mL |
| 5 mM | 0.28 mL | 1.38 mL | 2.75 mL |
*The above data is based on the productmolecular weight 726.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20158 |
|---|---|
| M. Wt | 726.31 |
| Formula | C38H36ClN5O4S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1354787-71-5 |
| SMILES | O=C(C(N1)=CC2=C1C=CC(NC(CCC(SSC)(C)C)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3 |
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