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DCC-2036 (Rebastinib)


Bcr-Abl 抑制剂

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产品目录号: A11200


产品名 目录号 价格 数量
DCC-2036 5mg A11200-5
¥ 1,400.00
DCC-2036 10mg A11200-10
¥ 2,200.00
DCC-2036 50mg A11200-50
¥ 6,000.00
DCC-2036 100mg A11200-100
¥ 9,800.00
DCC-2036 10mM * 1mL in DMSO A11200-10mM-D
¥ 2,140.00



DCC-2036 is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity.

DCC-2036 (Rebastinib)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 DCC-2036 (Rebastinib) 发表的文献 (1)
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635每646 PMID: 29917168

Chemical Information

目录号 A11200
Mechanism of action Inhibitor
分子量 553.59
化学分子式 C30H28FN7O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1020172-07-9
Synonyms DCC2036
SMILES code CC(C)(C)C1=NN(C(=C1)NC(=O)NC2=C(C=C(C=C2)OC3=CC(=NC=C3)C(=O)NC)F)C4=CC5=C(C=C4)N=CC=C5
化学名称 N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea



DCC-2036 is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity.

Target Value
u-Abl1(native)IC50: 0.75nM
Abl1(H396P)IC50: 1.4nM
p-Abl1(native)IC50: 2nM
FLT3IC50: 2nM
p-Abl1(T315I)IC50: 4nM
KDRIC50: 4nM
u-Abl1(T315I)IC50: 5nM
Tie-2IC50: 6nM
LynIC50: 29nM
SrcIC50: 34nM
FGRIC50: 38nM
HckIC50: 40nM
PDGFRαIC50: 70nM
PDGFRβIC50: 113nM
c-KitIC50: 481nM
AuroraAIC50: >5μM
CDK2/CyclinDIC50: >5μM


Solubility (25°C) * In vitro DMSO 111 mg/mL (200.5 mM)
Water <1 mg/mL (<1 mM)
Ethanol 16 mg/mL (28.9 mM)
In vivo 0.5% CMC/0.25% Tween 80 16 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.06 mL 90.32 mL 180.64mL
0.5 mM 3.61 mL 18.06 mL 36.13 mL
1 mM 1.81 mL 9.03 mL 18.06 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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