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Debio-1347 (CH5183284)

FGFR1/2/3 抑制剂

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产品目录号： A14415

库存状态：中国现货中国现货

产品名 目录号 价格 数量
Debio-1347 5mg A14415-5
￥ 1,100.00
Debio-1347 10mg A14415-10
￥ 1,900.00
Debio-1347 25mg A14415-25
￥ 3,300.00

产品仅用于研究，不针对患者销售，望谅解.

产品简介

Debio-1347 is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity.

Debio-1347 (CH5183284)

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Chemical Information

目录号 A14415
Mechanism of action Inhibitor
分子量 356.38
化学分子式 C20H16N6O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1265229-25-1
Synonyms Debio 1347, Debio1347, CH5183284, CH 5183284, CH-5183284, FF-284, FF284, FF 284
SMILES code CC1=NC2=C(N1)C=C(C=C2)N3C(=C(C=N3)C(=O)C4=CC5=CC=CC=C5N4)N
化学名称 (5-amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrazol-4-yl)(1H-indol-2-yl)methanone

生物活性

Description
 Debio-1347 is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity.
Targets
FGFR2 FGFR1 FGFR3 FGFR4
7.6 nM9.3 nM22 nM290 nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.06 mL 140.3 mL 280.6mL
0.5 mM 5.61 mL 28.06 mL 56.12 mL
1 mM 2.81 mL 14.03 mL 28.06 mL
5 mM 0.56 mL 2.81 mL 5.61 mL

*The above data is based on the productmolecular weight 356.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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