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Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.28 mL | 91.42 mL | 182.83 mL |
| 0.5 mM | 3.66 mL | 18.28 mL | 36.57 mL |
| 1 mM | 1.83 mL | 9.14 mL | 18.28 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.66 mL |
*The above data is based on the productmolecular weight 546.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22003 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 546.95 |
| Formula | C20H22ClF3N8O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1073160-26-5 |
| Synonyms | VS-6063 hydrochloride, VS6063, VS 6063; PF 04554878 hydrochloride, PF-04554878, PF04554878 |
| SMILES | O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(=O)(C)=O)=N2)C=C1.[H]Cl |
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