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Deferasirox

促销

Iron chelator

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产品目录号: A10293

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Deferasirox 5mg A10293-5
¥ 500.00
Deferasirox 10mg A10293-10
¥ 900.00
Deferasirox 25mg A10293-25
¥ 1,800.00
Deferasirox 50mg A10293-50
¥ 3,200.00
Deferasirox 10mM * 1mL in DMSO A10293-10mM-D
¥ 960.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Deferasirox is a rationally-designed oral iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor.

Deferasirox

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Chemical Information

目录号 A10293
Mechanism of action
分子量 373.36
化学分子式 C21H15N3O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 201530-41-8
Synonyms ICL-670, ICL-670A, CGP-72670
SMILES code C1=C/C(=C\2/N/C(=C\3/C=CC=CC3=O)/N(N2)C4=CC=C(C=C4)C(=O)O)/C(=O)C=C1
化学名称 [4-[(3Z,5E)-3,5-bis(6-oxo-1-cyclohexa-2,4-dienylidene)-1,2,4-triazolidin-1-yl]benzoic acid

生物活性

Description
Deferasirox is a rationally-designed oral iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor.

溶解性

Solubility (25°C) * In vitro DMSO 74 mg/mL (198.2 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (5.35 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.78 mL 133.92 mL 267.84mL
0.5 mM 5.36 mL 26.78 mL 53.57 mL
1 mM 2.68 mL 13.39 mL 26.78 mL
5 mM 0.54 mL 2.68 mL 5.36 mL

*The above data is based on the productmolecular weight 373.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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