Demcizumab (OMP 21M18) is a monoclonal antibody targeting DLL4, a critical regulator in the Notch signaling pathway. This antibody acts as a potent inhibitor of the Notch pathway, which plays a significant role in cell differentiation, proliferation, and apoptosis. The inhibition of this pathway by Demcizumab has demonstrated efficacy in various cancer models, both as a standalone treatment and in combination with chemotherapy. This makes it a valuable tool for research in cancer biology, particularly in studies exploring the role of Notch signaling in tumorigenesis and therapeutic resistance.
Demcizumab (OMP 21M18) is a monoclonal antibody targeting DLL4, a critical regulator in the Notch signaling pathway. This antibody acts as a potent inhibitor of the Notch pathway, which plays a significant role in cell differentiation, proliferation, and apoptosis. The inhibition of this pathway by Demcizumab has demonstrated efficacy in various cancer models, both as a standalone treatment and in combination with chemotherapy. This makes it a valuable tool for research in cancer biology, particularly in studies exploring the role of Notch signaling in tumorigenesis and therapeutic resistance.
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