Denosumab is a human monoclonal antibody specifically designed to target and bind to the receptor activator of nuclear factor kappa-B ligand (RANKL) with a dissociation constant (K_D) of 0.003 nM for human RANKL. By inhibiting the interaction between RANKL and its receptor, RANK, Denosumab effectively blocks the NF-??B signaling pathway, which is crucial in the regulation of bone metabolism and immune responses. This inhibition prevents bone resorption, a key factor in various bone diseases and disorders. Additionally, Denosumab has been observed to promote proliferation and spermatogenesis. This antibody is particularly useful in research focused on bone density regulation, osteoporosis, and related bone health studies.
Denosumab is a human monoclonal antibody specifically designed to target and bind to the receptor activator of nuclear factor kappa-B ligand (RANKL) with a dissociation constant (K_D) of 0.003 nM for human RANKL. By inhibiting the interaction between RANKL and its receptor, RANK, Denosumab effectively blocks the NF-??B signaling pathway, which is crucial in the regulation of bone metabolism and immune responses. This inhibition prevents bone resorption, a key factor in various bone diseases and disorders. Additionally, Denosumab has been observed to promote proliferation and spermatogenesis. This antibody is particularly useful in research focused on bone density regulation, osteoporosis, and related bone health studies.
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