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DG172 dihydrochloride

PPAR??/?? inverse 激动剂

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产品目录号: A16309

库存状态:中国现货中国现货

产品名 目录号 价格 数量
DG172 dihydrochloride 5mg A16309-5
¥ 500.00
DG172 dihydrochloride 10mg A16309-10
¥ 900.00
DG172 dihydrochloride 50mg A16309-50
¥ 3,600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

DG-172 is an orally active potent PPARβ/δ inverse agonist (IC50 = 26.9 nM). DG-172 inhibits Angptl4 gene expression in mouse myoblasts (IC50 = 9.5 nM) in vitro.

DG172 dihydrochloride

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Chemical Information

目录号 A16309
Mechanism of action Antagonist
分子量 455.22
化学分子式 C20H22BrCl2N3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1361504-77-9
Synonyms DG 172 dihydrochloride
SMILES code N#C/C(C1=CC=CC=C1Br)=C\C2=CC=C(N3CCN(C)CC3)C=C2.[H]Cl.[H]Cl
化学名称 (Z)-2-(2-bromophenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylonitrile dihydrochloride

生物活性

Description
DG-172 is an orally active potent PPARβ/δ inverse agonist (IC50 = 26.9 nM). DG-172 inhibits Angptl4 gene expression in mouse myoblasts (IC50 = 9.5 nM) in vitro.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.97 mL 109.84 mL 219.67mL
0.5 mM 4.39 mL 21.97 mL 43.93 mL
1 mM 2.2 mL 10.98 mL 21.97 mL
5 mM 0.44 mL 2.2 mL 4.39 mL

*The above data is based on the productmolecular weight 455.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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