Dinutuximab (Unituxin; APN-311) is a chimeric monoclonal antibody derived from both human and murine sources, specifically targeting GD2. This antibody has demonstrated significant efficacy in prolonging event-free and overall survival in patients with high-risk neuroblastoma. It is used in a therapeutic regimen that includes granulocyte-macrophage colony-stimulating factor (GM-CSF), aldesleukin (interleukin-2 [IL-2]), and isotretinoin (13-cis-retinoic acid [RA]), enhancing its effectiveness in clinical applications.
Dinutuximab (Unituxin; APN-311) is a chimeric monoclonal antibody derived from both human and murine sources, specifically targeting GD2. This antibody has demonstrated significant efficacy in prolonging event-free and overall survival in patients with high-risk neuroblastoma. It is used in a therapeutic regimen that includes granulocyte-macrophage colony-stimulating factor (GM-CSF), aldesleukin (interleukin-2 [IL-2]), and isotretinoin (13-cis-retinoic acid [RA]), enhancing its effectiveness in clinical applications.
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