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产品名
应用
产品描述
文献引用
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PARP1 抑制剂
Niraparib R-enantiomer (MK-4827 R-enantiomer) 是一种优秀的 PARP1 抑制剂，其 IC50 为 2.4 nM。 -
NAD+ competitive 抑制剂 of PARP7
RBN-2397 是一种效力强大、跨物种且可口服的 NAD+ 竞争性抑制剂，针对 PARP7（IC50<3 nM）。 -
anticancer agent
5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP), a renowned medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein. 5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration-dependent manner.
