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Dolasetron is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much antiemetic effect when symptoms are due to motion sickness.
| In vitro | DMSO | 61 mg/mL (188.05 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.83 mL | 154.14 mL | 308.29 mL |
| 0.5 mM | 6.17 mL | 30.83 mL | 61.66 mL |
| 1 mM | 3.08 mL | 15.41 mL | 30.83 mL |
| 5 mM | 0.62 mL | 3.08 mL | 6.17 mL |
*The above data is based on the productmolecular weight 324.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17595 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 324.37 |
| Formula | C19H20N2O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 115956-12-2 |
| Synonyms | HSDB 7565; HSDB7565; HSDB-7565; Dolasetron; Dolasetronum |
| SMILES | O=C(C1=CNC2=C1C=CC=C2)OC(CC3N4C5)C[C@@]4([H])CC(C3)C5=O |
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