Dolasetron
目录号: A17595
5-HT3 receptor 拮抗剂
多拉司琼是一种5-HT3受体拮抗剂，用于治疗化疗后的恶心和呕吐。其主要作用是减少迷走神经的活动，迷走神经是激活延髓呕吐中心的神经。当症状由晕动病引起时，它没有太多的止吐效果。
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生物活性
| Discription | Dolasetron is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much antiemetic effect when symptoms are due to motion sickness. | ||
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产品信息
| 目录号 | A17595 |
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| 分子式 | C19H20N2O3 |
| 分子量 | 324.37 |
| CAS号 | 115956-12-2 |
| SMILES | O=C(C1=CNC2=C1C=CC=C2)OC(CC3N4C5)C[C@@]4([H])CC(C3)C5=O |
| 其他名称 | HSDB 7565; HSDB7565; HSDB-7565; Dolasetron; Dolasetronum |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 61 mg/mL (188.05 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.83 mL | 154.14 mL | 308.29 mL |
| 0.5 mM | 6.17 mL | 30.83 mL | 61.66 mL |
| 1 mM | 3.08 mL | 15.41 mL | 30.83 mL |
| 5 mM | 0.62 mL | 3.08 mL | 6.17 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 115956-12-2 | 115956-12-2 供应商 | 115956-12-2 花费 | 115956-12-2 生产商 | 订购 115956-12-2 | 115956-12-2 代理商