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Dolutegravir Sodium

HIV integrase 抑制剂

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产品目录号: A16162


产品名 目录号 价格 数量
Dolutegravir Sodium 5mg A16162-5
¥ 700.00
Dolutegravir Sodium 10mg A16162-10
¥ 950.00
Dolutegravir Sodium 50mg A16162-50
¥ 3,990.00



Dolutegravir sodium is a HIV integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.

Dolutegravir Sodium




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Chemical Information

目录号 A16162
Mechanism of action Inhibitor
分子量 441.36
化学分子式 C20H18F2N3NaO5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1051375-19-9
Synonyms DTG, GSK1349572
SMILES code CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)[O-].[Na+]
化学名称 sodium;(4R,12aS)-9-[(2,4-difluorophenyl)methylcarbamoyl]-4-methyl-6,8-dioxo-3,4,12,12a-tetrahydro-2H-pyrido[5,6]pyrazino[2,6-b][1,3]oxazin-7-olate


Dolutegravir sodium is a HIV integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
HIV integrase
2.7 nM


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.66 mL 113.29 mL 226.57mL
0.5 mM 4.53 mL 22.66 mL 45.31 mL
1 mM 2.27 mL 11.33 mL 22.66 mL
5 mM 0.45 mL 2.27 mL 4.53 mL

*The above data is based on the productmolecular weight 441.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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