Domvanalimab (AB154) is a humanized monoclonal antibody targeting TIGIT (T cell immunoreceptor with Ig and ITIM domains). This antibody selectively binds to human TIGIT, effectively inhibiting the interaction between TIGIT and its ligand CD155. Domvanalimab is primarily utilized in oncological research to explore the modulation of immune responses against cancer cells. This inhibition potentially enhances T cell activation and NK cell cytotoxicity, offering a promising avenue for cancer immunotherapy studies.
Domvanalimab (AB154) is a humanized monoclonal antibody targeting TIGIT (T cell immunoreceptor with Ig and ITIM domains). This antibody selectively binds to human TIGIT, effectively inhibiting the interaction between TIGIT and its ligand CD155. Domvanalimab is primarily utilized in oncological research to explore the modulation of immune responses against cancer cells. This inhibition potentially enhances T cell activation and NK cell cytotoxicity, offering a promising avenue for cancer immunotherapy studies.
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