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Doramapimod (BIRB-796)


p38 MAPK 抑制剂

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产品目录号: A10148


产品名 目录号 价格 数量
Doramapimod 5mg A10148-5
¥ 300.00
Doramapimod 10mg A10148-10
¥ 500.00
Doramapimod 50mg A10148-50
¥ 1,350.00
Doramapimod 100mg A10148-100
¥ 1,800.00
Doramapimod (BIRB-796) 10mM * 1mL in DMSO A10148-10mM-D
¥ 500.00



Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.

Doramapimod (BIRB-796)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Doramapimod (BIRB-796) 发表的文献 (1)
  • Perera LMB, .et al. The regulation of skin fibrosis in systemic sclerosis by extracellular ATP via P2Y2 purinergic receptor, J Invest Dermatol, 2018, Nov 4. pii: S0022-202X(18)32791-X PMID: 30404019

Chemical Information

目录号 A10148
Mechanism of action Inhibitor
分子量 527.7
化学分子式 C31H37N5O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 285983-48-4
Synonyms BIRB-796,BIRB 796
化学名称 N-[3-tert-Butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]naphthalen-1-yl]urea


Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
p38α (Cell-free assay) p38α
0.1 nM(Kd)38 nM


Solubility (25°C) * In vitro DMSO 106 mg/mL (200.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol 106 mg/mL (200.88 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.95 mL 94.75 mL 189.5mL
0.5 mM 3.79 mL 18.95 mL 37.9 mL
1 mM 1.9 mL 9.48 mL 18.95 mL
5 mM 0.38 mL 1.9 mL 3.79 mL

*The above data is based on the productmolecular weight 527.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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