Dostarlimab (TSR-042) is a humanized monoclonal antibody targeting PD-1 (Programmed Death-1). This antibody exhibits high affinity binding to PD-1, effectively blocking its interaction with the ligands PD-L1 and PD-L2. The inhibition constants (IC50) are determined to be 1.8 nM for PD-L1 and 1.5 nM for PD-L2, respectively. Dostarlimab serves as a potent inhibitor in the modulation of immune responses, making it a valuable tool in immunotherapy research.
Dostarlimab (TSR-042) is a humanized monoclonal antibody targeting PD-1 (Programmed Death-1). This antibody exhibits high affinity binding to PD-1, effectively blocking its interaction with the ligands PD-L1 and PD-L2. The inhibition constants (IC50) are determined to be 1.8 nM for PD-L1 and 1.5 nM for PD-L2, respectively. Dostarlimab serves as a potent inhibitor in the modulation of immune responses, making it a valuable tool in immunotherapy research.
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