Doxazosin
目录号: A17779
α-1 adrenergic receptor blocker
多沙唑嗪是一种α-1肾上腺素能受体阻断剂，它抑制从交感神经末梢释放的去甲肾上腺素与血管平滑肌细胞膜上的α-1受体的结合。阻断α-1肾上腺素能作用于血管平滑肌会导致血管阻力下降和降压活性。
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生物活性
| Discription | Doxazosin is an α-1 adrenergic receptor blocker that inhibits the binding of norepinephrine, which is released from sympathetic nerve terminals, to the α-1 receptors on the membrane of vascular smooth muscle cells. Blockages of the alpha-1 adrenergic action on the vascular smooth muscles lead to a decrease in vascular resistance and antihypertensive activity. | |||||
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| Cell Research |
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产品信息
| 目录号 | A17779 |
|---|---|
| 分子式 | C23H25N5O5 |
| 分子量 | 451.48 |
| CAS号 | 74191-85-8 |
| SMILES | COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC |
| 其他名称 | Doxazosin; Cardura; 74191-85-8; Doxazosinum; Doxazosina; Doxazosine; Alfamedin; Aliud Brand of Doxazosin Mesylate; Almirall Brand of Doxazosin Mesylate; Alpharma Brand of Doxazosin Mesylate; Alter Brand of Doxazosin Mesylate; Apo Doxazosin; Apo-Doxazosin; |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 29 mg/mL (64.23 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.15 mL | 110.75 mL | 221.49 mL |
| 0.5 mM | 4.43 mL | 22.15 mL | 44.3 mL |
| 1 mM | 2.21 mL | 11.07 mL | 22.15 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.43 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 74191-85-8 | 74191-85-8 供应商 | 74191-85-8 花费 | 74191-85-8 生产商 | 订购 74191-85-8 | 74191-85-8 代理商