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Dynasore

促销

Dynamin 抑制剂

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产品目录号: A12726

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Dynasore 10mg A12726-10
¥ 400.00
Dynasore 25mg A12726-25
¥ 800.00
Dynasore 50mg A12726-50
¥ 1,400.00
Dynasore 100mg A12726-100
¥ 2,500.00
Dynasore 10mM * 1mL in DMSO A12726-10mM-D
¥ 720.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Dynasore is a non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity

Dynasore

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Dynasore 发表的文献 (3)
  • Tsukamoto H, .et al. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKK?-IRF3 axis activation, J Biol Chem, 2018, Jun 29;293(26):10186-10201 PMID: 29760187
  • Shigetoshi Yokoyama, .et al. A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death, eLife, 2018, 7: e37854 PMID: 30526845
  • Naoko Fujii, .et al. Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells, J Biol Chem, 2016, Nov 18; 291(47): 24787每24799 PMID: 27733684

Chemical Information

目录号 A12726
Mechanism of action Inhibitor
分子量 322.32
化学分子式 C18H14N2O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 304448-55-3
Synonyms N/A
SMILES code C1=CC=C2C=C(C(=CC2=C1)C(=O)NN/C=C/3\C=CC(=O)C(=C3)O)O
化学名称 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide

生物活性

Description
Dynasore is a non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity
Targets
Dynamin1/2 (Cell-free assay)
~15 μM

溶解性

Solubility (25°C)* In vitro DMSO 64 mg/mL (198.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.03 mL 155.13 mL 310.25mL
0.5 mM 6.21 mL 31.03 mL 62.05 mL
1 mM 3.1 mL 15.51 mL 31.03 mL
5 mM 0.62 mL 3.1 mL 6.21 mL

*The above data is based on the productmolecular weight 322.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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