E7080 (Lenvatinib)

目录号: A10340

VEGFR 抑制剂

E7080 (Lenvatinib)

E7080 (Lenvatinib) Chemical Structure

CAS NO. 417716-92-8

E7080 (Lenvatinib)是一种多激酶抑制剂,可同时抑制VEGFR2和VEGFR3激酶。

库存: 现货

规格 价格 数量
5 mg
¥ 500.00
10 mg
¥ 700.00
50 mg
¥ 1,500.00
100 mg
¥ 2,000.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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E7080 (Lenvatinib)是一种多激酶抑制剂,可同时抑制VEGFR2和VEGFR3激酶。
Targets
Target Value
VEGFR2/KDRIC50: 4.0nM
VEGFR3/FLT4IC50: 5.2nM
VEGFR1/FLT1IC50: 22nM
PDGFRβIC50: 39nM
FGFR1IC50: 46nM
PDGFRαIC50: 51nM
KitIC50: 100nM
EphB4IC50: >10μM
IGF-1RIC50: >10μM
Insulin ReceptorIC50: >10μM
SrcIC50: >10μM
Akt1IC50: >10μM
CDK4/CyclinDIC50: >10μM
PLK1IC50: >10μM
FAKIC50: >10μM
PKCαIC50: >10μM
In vitro (25°C) DMSO Warmed: 35 mg/mL (81.99 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% methylcellulose 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.42 mL 117.12 mL 234.25 mL
0.5 mM 4.68 mL 23.42 mL 46.85 mL
1 mM 2.34 mL 11.71 mL 23.42 mL
5 mM 0.47 mL 2.34 mL 4.68 mL

*The above data is based on the productmolecular weight 426.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10340
作用机制 Inhibitor (抑制剂)
M. Wt 426.9
Formula C21H19ClN4O4
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 417716-92-8
Synonyms E-7080
SMILES COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl

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