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E7080 (Lenvatinib)

促销

VEGFR 抑制剂

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产品目录号: A10340

库存状态:中国现货中国现货

产品名 目录号 价格 数量
E7080 5mg A10340-5
¥ 500.00
E7080 10mg A10340-10
¥ 700.00
E7080 50mg A10340-50
¥ 1,500.00
E7080 100mg A10340-100
¥ 2,500.00
E7080 (Lenvatinib) 10mM * 1mL in DMSO A10340-10mM-D
¥ 550.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.

E7080 (Lenvatinib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 E7080 (Lenvatinib) 发表的文献 (3)
  • Koide H, .et al. Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1, Xenobiotica, 2018, Oct;48(10):1059-1071 PMID: 29034773
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Tomoko Ogawa-Morita, .et al. Validation of a Liquid Chromatography-Tandem Mass Spectrometric Assay for Quantitative Analysis of Lenvatinib in Human Plasma, Int J Anal Chem, 2017, 2017: 2341876 PMID: 28680445

Chemical Information

目录号 A10340
Mechanism of action Inhibitor
分子量 426.9
化学分子式 C21H19ClN4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 417716-92-8
Synonyms E-7080
SMILES code COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl
化学名称 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxy-quinoline-6-carboxamid

生物活性

Description
E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.
Targets
Target Value
VEGFR2/KDRIC50: 4.0nM
VEGFR3/FLT4IC50: 5.2nM
VEGFR1/FLT1IC50: 22nM
PDGFRβIC50: 39nM
FGFR1IC50: 46nM
PDGFRαIC50: 51nM
KitIC50: 100nM
EphB4IC50: >10μM
IGF-1RIC50: >10μM
Insulin ReceptorIC50: >10μM
SrcIC50: >10μM
Akt1IC50: >10μM
CDK4/CyclinDIC50: >10μM
PLK1IC50: >10μM
FAKIC50: >10μM
PKCαIC50: >10μM

溶解性

Solubility (25°C) * In vitro DMSO 40 mg/mL (93.7 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.42 mL 117.12 mL 234.25mL
0.5 mM 4.68 mL 23.42 mL 46.85 mL
1 mM 2.34 mL 11.71 mL 23.42 mL
5 mM 0.47 mL 2.34 mL 4.68 mL

*The above data is based on the productmolecular weight 426.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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