EB-47 is a selective inhibitor of PARP-1 (ARTD-1) with an IC50 value of 45 nM, demonstrating its strong inhibition profile. It also exhibits modest potency against ARTD5 with an IC50 of 410 nM. Structurally, EB-47 mimics the substrate NAD+, extending from the nicotinamide to the adenosine subsite, making it a valuable tool for studying DNA repair mechanisms and related cancer research applications.
EB-47 is a selective inhibitor of PARP-1 (ARTD-1) with an IC50 value of 45 nM, demonstrating its strong inhibition profile. It also exhibits modest potency against ARTD5 with an IC50 of 410 nM. Structurally, EB-47 mimics the substrate NAD+, extending from the nicotinamide to the adenosine subsite, making it a valuable tool for studying DNA repair mechanisms and related cancer research applications.
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