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Ebselen (SPI-1005) is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen can permeate the blood-brain barrier and inhibit inositol monophosphatase (IMPase). Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen inhibits QSOX1 enzymatic activity and has anticancer activity .
| In vitro | DMSO | 52 mg/mL (189.65 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 36.47 mL | 182.35 mL | 364.7 mL |
| 0.5 mM | 7.29 mL | 36.47 mL | 72.94 mL |
| 1 mM | 3.65 mL | 18.23 mL | 36.47 mL |
| 5 mM | 0.73 mL | 3.65 mL | 7.29 mL |
*The above data is based on the productmolecular weight 274.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20834 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 274.2 |
| Formula | C13H9NOSe |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 60940-34-3 |
| Synonyms | SPI1005, SPI 1005, SPI-1005, PZ-51, PZ 51, PZ51, CCG-39161, CCG39161, CCG 39161 |
| SMILES | O=C1N(C2=CC=CC=C2)[Se]C3=C1C=CC=C3 |
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