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Echinomycin

HIF-1?? 抑制剂

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产品目录号: A14021

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Echinomycin 5mg A14021-5
¥ 2,200.00
Echinomycin 10mg A14021-10
¥ 4,000.00
Echinomycin 25mg A14021-25
¥ 9,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription

Echinomycin

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Chemical Information

目录号 A14021
Mechanism of action Inhibitor
分子量 1101.3
化学分子式 C51H64N12O12S2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 512-64-1
Synonyms Antibiotic A 654I, NSC 526417, Quinomycin A, SK 302B, NSC 13502
SMILES code CC1C(=O)N(C2CSC(C(C(=O)N(C(C(=O)OC[C@H](C(=O)N1)NC(=O)C3=NC4=CC=CC=C4N=C3)C(C)C)C)N(C(=O)C(NC(=O)[C@@H](COC(=O)C(N(C2=O)C)C(C)C)NC(=O)C5=NC6=CC=CC=C6N=C5)C)C)SC)C
化学名称 N-(2-quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-(8??1)-lactone,cyclic (3??7)-thioether-L-valine

生物活性

Description
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 9.08 mL 45.4 mL 90.8mL
0.5 mM 1.82 mL 9.08 mL 18.16 mL
1 mM 0.91 mL 4.54 mL 9.08 mL
5 mM 0.18 mL 0.91 mL 1.82 mL

*The above data is based on the productmolecular weight 1101.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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