EGFR-IN-12 (EGFR Inhibitor)
目录号: A13673
EGFR 抑制剂
EGFR抑制剂是一种细胞可渗透的4,6-二取代嘧啶化合物，能够选择性地抑制EGFR激酶，在体外的IC50值为21 nM，并且能够阻断细胞中受体的自磷酸化。
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生物活性
| Discription | EGFR inhibitor is a cell permeable, 4,6-disubstituted pyrimidine compound that selectively inhibits the EGFR kinase with an IC50 value of 21 nM in vitro and blocks receptor autophosphorylation in cells. | ||
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产品信息
| 目录号 | A13673 |
|---|---|
| 分子式 | C21H18F3N5O |
| 分子量 | 413.4 |
| CAS号 | 879127-07-8 |
| SMILES | C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=NC(=C3)NC4=CC=CC(=C4)C(F)(F)F |
| 其他名称 | Epidermal Growth Factor Receptor Inhibitor |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 79 mg/mL (191.09 mM) | |
| Water | <1 mg/mL | ||
| Ethanol | 2 mg/mL (4.83 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.19 mL | 120.95 mL | 241.9 mL |
| 0.5 mM | 4.84 mL | 24.19 mL | 48.38 mL |
| 1 mM | 2.42 mL | 12.09 mL | 24.19 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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