Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody designed for high selectivity toward repulsive guidance molecule A (RGMa). This antibody effectively inhibits RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, demonstrating a potent inhibitory concentration (IC50) of approximately 97 pM. Elezanumab binds to the N-terminal of RGMa, effectively blocking BMP signaling pathways and demonstrating no cross-reactivity with RGMc. It has been shown to promote both neuroregeneration and neuroprotection across various models of neuronal injury and demyelination. Importantly, Elezanumab exerts its neuroregenerative and neuroprotective effects without affecting iron metabolism, making it a targeted therapeutic option for neurological research and potential clinical applications.
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody designed for high selectivity toward repulsive guidance molecule A (RGMa). This antibody effectively inhibits RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, demonstrating a potent inhibitory concentration (IC50) of approximately 97 pM. Elezanumab binds to the N-terminal of RGMa, effectively blocking BMP signaling pathways and demonstrating no cross-reactivity with RGMc. It has been shown to promote both neuroregeneration and neuroprotection across various models of neuronal injury and demyelination. Importantly, Elezanumab exerts its neuroregenerative and neuroprotective effects without affecting iron metabolism, making it a targeted therapeutic option for neurological research and potential clinical applications.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
