ELR510444
目录号: A15455
Microtubule Disruptor
ELR510444 是一种新型的微管破坏剂；在抑制 MDA-MB-231 细胞增殖方面，IC50 为 30.9 nM；不是 P-糖蛋白药物转运体的底物，并且在 βIII-微管蛋白 过表达的细胞系中保持活性。
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生物活性
| Discription | ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in ??III-tubulin-overexpressing cell lines. |
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产品信息
| 目录号 | A15455 |
|---|---|
| 分子式 | C19H16N2O2S2 |
| 分子量 | 368.47 |
| CAS号 | 1233948-35-0 |
| SMILES | CC1=CC=C(S(NC2=C(C=CC(C3=CC=C(S3)C#N)=C2)C)(=O)=O)C=C1 |
| 其他名称 | ELR-510444, ELR 510444 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 72 mg/mL (195.4 mM) | |
| Water | Insoluble | ||
| Ethanol | 24 mg/mL (65.13 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.14 mL | 135.7 mL | 271.39 mL |
| 0.5 mM | 5.43 mL | 27.14 mL | 54.28 mL |
| 1 mM | 2.71 mL | 13.57 mL | 27.14 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.43 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1233948-35-0 | 1233948-35-0 供应商 | 1233948-35-0 花费 | 1233948-35-0 生产商 | 订购 1233948-35-0 | 1233948-35-0 代理商