Emapalumab (NI-0501) is a human monoclonal IgG1 antibody designed for the noncompetitive inhibition of interferon gamma (IFN-??). It exhibits high binding affinity, with a dissociation constant (Kd) of 1.4 pM, to both free IFN-?? and IFN-?? that is bound to its receptor. This antibody is particularly useful in the study of hemophagocytic lymphohistiocytosis (HLH), providing a critical tool for research into the pathophysiology and potential therapeutic interventions for this condition.
Emapalumab (NI-0501) is a human monoclonal IgG1 antibody designed for the noncompetitive inhibition of interferon gamma (IFN-??). It exhibits high binding affinity, with a dissociation constant (Kd) of 1.4 pM, to both free IFN-?? and IFN-?? that is bound to its receptor. This antibody is particularly useful in the study of hemophagocytic lymphohistiocytosis (HLH), providing a critical tool for research into the pathophysiology and potential therapeutic interventions for this condition.
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