Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody that specifically targets complement component C2. By binding to the Sushi-2 domain of C2, Empasiprubar effectively prevents the formation of C3 convertase, thereby inhibiting the activation of both the classical and lectin complement pathways upstream of C3. This inhibition is critical in mitigating the effects of complement-mediated autoimmune disorders, such as autoimmune hemolytic anemia, and in preventing antibody-mediated rejection in organ transplantation. Additionally, Empasiprubar has demonstrated potential in preventing neuroglial and lymphoconjunctival injuries in GM1 antibody-mediated mouse models, suggesting further applications in neuroinflammatory conditions. This antibody offers a promising therapeutic approach by targeting a key point in the complement activation cascade, providing broad utility in research focused on immune regulation and complement system-mediated diseases.
Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody that specifically targets complement component C2. By binding to the Sushi-2 domain of C2, Empasiprubar effectively prevents the formation of C3 convertase, thereby inhibiting the activation of both the classical and lectin complement pathways upstream of C3. This inhibition is critical in mitigating the effects of complement-mediated autoimmune disorders, such as autoimmune hemolytic anemia, and in preventing antibody-mediated rejection in organ transplantation. Additionally, Empasiprubar has demonstrated potential in preventing neuroglial and lymphoconjunctival injuries in GM1 antibody-mediated mouse models, suggesting further applications in neuroinflammatory conditions. This antibody offers a promising therapeutic approach by targeting a key point in the complement activation cascade, providing broad utility in research focused on immune regulation and complement system-mediated diseases.
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