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ENMD-2076

促销

Aurora A / FLT3 抑制剂

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产品目录号: A10352

库存状态:中国现货中国现货

产品名 目录号 价格 数量
ENMD-2076 5mg A10352-5
¥ 800.00
ENMD-2076 10mg A10352-10
¥ 1,400.00
ENMD-2076 50mg A10352-50
¥ 4,000.00
ENMD-2076 100mg A10352-100
¥ 6,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.

ENMD-2076

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Chemical Information

目录号 A10352
Mechanism of action Inhibitor
分子量 375.5
化学分子式 C21H25N7
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 934353-76-1, 1291074-87-7
Synonyms ENMD2076, ENMD 2076
SMILES code CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)/C=C/C4=CC=CC=C4
化学名称 (E)-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine

生物活性

Description
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.
Targets
Target Value
FLT3IC50: 1.86nM
RETIC50: 10.4nM
AuroraAIC50: 14nM
VEGFR3/FLT4IC50: 15.9nM
SrcIC50: 20.2nM
NTRK1/TRKAIC50: 24.2nM
CSF-1R/c-FmsIC50: 24.8nM
LCKIC50: 43.7nM
FAKIC50: 54.9nM
PDGFRαIC50: 56.4nM
VEGFR2/KDRIC50: 58.2nM
BLKIC50: 69.4nM
FGFR2IC50: 70.8nM
YES1IC50: 78.4nM
Abl1(T315I)IC50: 81.3nM
FGFR1IC50: 92.7nM
FynIC50: 112nM
JAK2IC50: 120nM
KitIC50: 120nM
AuroraBIC50: 350nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.63 mL 133.16 mL 266.31mL
0.5 mM 5.33 mL 26.63 mL 53.26 mL
1 mM 2.66 mL 13.32 mL 26.63 mL
5 mM 0.53 mL 2.66 mL 5.33 mL

*The above data is based on the productmolecular weight 375.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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