Entrectinib

目录号: A15801

TRK, ROS1, ALK inhibitor

Entrectinib

Entrectinib Chemical Structure

CAS NO. 1108743-60-7

Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.

库存: 现货

规格 价格 数量
10 mg
¥ 1,200.00
25 mg
¥ 2,650.00
5 mg
¥ 750.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.
Targets
TrkA TrkB TrkC ROS1 ALK
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.84 mL 89.18 mL 178.37 mL
0.5 mM 3.57 mL 17.84 mL 35.67 mL
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL

*The above data is based on the productmolecular weight 560.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A15801
MECHANISM OF ACTION Inhibitor
M. Wt 560.64
Formula C31H34F2N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1108743-60-7
Synonyms RXDX-101, RXDX-101, RXDX-101, NMS E628, NMS-E628, NMSE628
SMILES CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6

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