Epacadostat (INCB024360)

目录号: A15554

IDO 抑制剂

Epacadostat (INCB024360)

Epacadostat (INCB024360) Chemical Structure

CAS NO. 1204669-58-8, 1204669-37-3

Epacadostat (INCB024360)是一种有效的选择性吲哚胺2,3-二加氧酶(IDO1)抑制剂,第2期的IC50为10 nM。

库存: 现货

规格 价格 数量
5 mg
¥ 450.00
10 mg
¥ 770.00
25 mg
¥ 1,350.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Epacadostat (INCB024360)是一种有效的选择性吲哚胺2,3-二加氧酶(IDO1)抑制剂,第2期的IC50为10 nM。
靶点信息
IDO1
10 nM
In vitro (25°C) DMSO 74 mg/mL (168.86 mM)
Water Insoluble
Ethanol Warmed: 45 mg/mL
In vivo 5% DMSO+40% PEG 300+5% TWEEN 80+50 % ddH2O 4.13 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.82 mL 114.1 mL 228.19 mL
0.5 mM 4.56 mL 22.82 mL 45.64 mL
1 mM 2.28 mL 11.41 mL 22.82 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A15554
作用机制 Inhibitor (抑制剂)
M. Wt 438.23
Formula C11H13BrFN7O4S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1204669-58-8, 1204669-37-3
Synonyms INCB 024360
SMILES C1=CC(=C(C=C1NC(=C2C(=NON2)NCCNS(=O)(=O)N)N=O)Br)F

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