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Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib shows potent antitumor activity.
| In vitro | DMSO | 88 mg/mL (147.53 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.77 mL | 83.83 mL | 167.65 mL |
| 0.5 mM | 3.35 mL | 16.77 mL | 33.53 mL |
| 1 mM | 1.68 mL | 8.38 mL | 16.77 mL |
| 5 mM | 0.34 mL | 1.68 mL | 3.35 mL |
*The above data is based on the productmolecular weight 596.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21950 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 596.48 |
| Formula | C30H28Cl2FN5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2071195-74-7 |
| Synonyms | S-22611 hydrochloride, S22611, S 22611 |
| SMILES | CC#C/C(C1=CC2=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)N=CN=C2C=C1)=N\OC[C@@H]5NCCOC5.Cl |
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