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EPZ-5676 (Pinometostat)


DOT1L 抑制剂?€?

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产品目录号: A12735


产品名 目录号 价格 数量
EPZ-5676 5mg A12735-5
¥ 800.00
EPZ-5676 10mg A12735-10
¥ 1,500.00
EPZ-5676 25mg A12735-25
¥ 3,000.00
EPZ-5676 50mg A12735-50
¥ 5,000.00
EPZ-5676 10mM * 1mL in DMSO A12735-10mM-D
¥ 1,490.00



EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity.

EPZ-5676 (Pinometostat)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 EPZ-5676 (Pinometostat) 发表的文献 (1)
  • Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48

Chemical Information

目录号 A12735
Mechanism of action Inhibitor
分子量 562.7
化学分子式 C30H42N8O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1380288-87-8
Synonyms EPZ5676, EPZ 5676
SMILES code CC(C)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C2N=CN=C3N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C
化学名称 (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol


EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity.
DOT1L (Cell-free assay)
80 pM(Ki)


Solubility (25°C) * In vitro DMSO 100 mg/mL (177.71 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (177.71 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.77 mL 88.86 mL 177.71mL
0.5 mM 3.55 mL 17.77 mL 35.54 mL
1 mM 1.78 mL 8.89 mL 17.77 mL
5 mM 0.36 mL 1.78 mL 3.55 mL

*The above data is based on the productmolecular weight 562.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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