EPZ-6438 (Tazemetostat)

Name: EPZ-6438 (Tazemetostat)
SKU: A12712
Price: 315 CNY
Rating: 5 (3 reviews)

目录号: A12712

EZH2 抑制剂

3 篇发表文献

EPZ-6438 是一种强效、选择性且口服生物利用度高的小分子抑制剂，专门针对 EZH2 酶活性。它能特异性地在 SMARCB1 缺失的 MRT 细胞中诱导凋亡和分化。

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Grouped product items
规格	价格	库存
5mg	¥315.00	现货
10mg	¥455.00	现货
25mg	¥595.00	现货
50mg	¥595.00	现货
100mg	¥1,120.00	现货
200mg	¥1,820.00	现货
500mg	¥3,430.00	现货
*10mM 1mL in DMSO**	¥385.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

Other Forms of EPZ-6438 (Tazemetostat)

Tazemetostat hydrobromide

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用EPZ-6438 (Tazemetostat)发表的3篇文献

Yang PM, .et al. , Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078

Wang Z, .et al. , J Cell Mol Med, 2019, May 13 PMID: 31087496

Theresa Baker, .et al. , Oncotarget, 2015, Oct 20; 6(32): 32646-32655 PMID: 26360609

生物活性

Discription

EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A12712
分子式	C34H44N4O4
分子量	572.74
CAS号	1403254-99-8
SMILES	CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5
其他名称	EPZ6438, EPZ 6438
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 4 mg/mL (6.98 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.46 mL	87.3 mL	174.6 mL
0.5 mM	3.49 mL	17.46 mL	34.92 mL
1 mM	1.75 mL	8.73 mL	17.46 mL
5 mM	0.35 mL	1.75 mL	3.49 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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