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EPZ-6438 (Tazemetostat)


EZH2 抑制剂

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产品目录号: A12712


产品名 目录号 价格 数量
EPZ-6438 5mg A12712-5
¥ 500.00
EPZ-6438 10mg A12712-10
¥ 700.00
EPZ-6438 25mg A12712-25
¥ 1,000.00
EPZ-6438 50mg A12712-50
¥ 1,500.00
EPZ-6438 10mM * 1mL in DMSO A12712-10mM-D
¥ 600.00



EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.

EPZ-6438 (Tazemetostat)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 EPZ-6438 (Tazemetostat) 发表的文献 (1)
  • Theresa Baker, .et al. Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors, Oncotarget, 2015, Oct 20; 6(32): 32646每32655 PMID: 26360609

Chemical Information

目录号 A12712
Mechanism of action Inhibitor
分子量 572.74
化学分子式 C34H44N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1403254-99-8
Synonyms EPZ6438, EPZ 6438
化学名称 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide


EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
EZH2 (Cell-free assay) EZH2 (Cell-free assay)
2.5 nM(Ki)2.5 nM(Ki)


Solubility (25°C)* In vitro DMSO 29 mg/mL (50.63 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.46 mL 87.3 mL 174.6mL
0.5 mM 3.49 mL 17.46 mL 34.92 mL
1 mM 1.75 mL 8.73 mL 17.46 mL
5 mM 0.35 mL 1.75 mL 3.49 mL

*The above data is based on the productmolecular weight 572.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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