EPZ-6438 (Tazemetostat)

目录号: A12712

EZH2 inhibitor

EPZ-6438 (Tazemetostat)

EPZ-6438 (Tazemetostat) Chemical Structure

CAS NO. 1403254-99-8

EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.

库存: 现货

规格 价格 数量
5 mg
¥ 500.00
10 mg
¥ 700.00
25 mg
¥ 1,000.00
50 mg
¥ 1,500.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
Targets
EZH2 (Cell-free assay) EZH2 (Cell-free assay)
2.5 nM(Ki)2.5 nM(Ki)
In vitro DMSO 29 mg/mL (50.63 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.46 mL 87.3 mL 174.6 mL
0.5 mM 3.49 mL 17.46 mL 34.92 mL
1 mM 1.75 mL 8.73 mL 17.46 mL
5 mM 0.35 mL 1.75 mL 3.49 mL

*The above data is based on the productmolecular weight 572.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A12712
MECHANISM OF ACTION Inhibitor
M. Wt 572.74
Formula C34H44N4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1403254-99-8
Synonyms EPZ6438, EPZ 6438
SMILES CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5

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