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EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.36 mL | 86.79 mL | 173.57 mL |
| 0.5 mM | 3.47 mL | 17.36 mL | 34.71 mL |
| 1 mM | 1.74 mL | 8.68 mL | 17.36 mL |
| 5 mM | 0.35 mL | 1.74 mL | 3.47 mL |
*The above data is based on the productmolecular weight 576.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21766 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 576.13 |
| Formula | C28H42ClN7O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1380316-03-9 |
| Synonyms | EPZ 004777, EPZ-004777 |
| SMILES | NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CN(C(C)C)CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)O3)C=C2)=NC=N1.[H]Cl |
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